Pinpointing brainstem mechanisms responsible for autonomic dysfunction in Rett syndrome: therapeutic perspectives for 5-HT1A agonists
Rett syndrome is a neurological disorder caused by loss of function of methyl-CpG-binding protein 2 (MeCP2).Reduced function of this ubiquitous transcriptional regulator has a devastating effect on the central nervous system.One of the most severe and life-threatening presentations of this syndrome is brainstem dysfunction, which results in Power B