PINPOINTING BRAINSTEM MECHANISMS RESPONSIBLE FOR AUTONOMIC DYSFUNCTION IN RETT SYNDROME: THERAPEUTIC PERSPECTIVES FOR 5-HT1A AGONISTS

Pinpointing brainstem mechanisms responsible for autonomic dysfunction in Rett syndrome: therapeutic perspectives for 5-HT1A agonists

Rett syndrome is a neurological disorder caused by loss of function of methyl-CpG-binding protein 2 (MeCP2).Reduced function of this ubiquitous transcriptional regulator has a devastating effect on the central nervous system.One of the most severe and life-threatening presentations of this syndrome is brainstem dysfunction, which results in Power B

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Freedom to Move: Free Lactation Pens Improve Sow Welfare

Farrowing crates present a major animal welfare problem.This study investigated the effects of temporary confinement at farrowing on sow welfare and aimed to determine whether this type of system could improve sow welfare through increased freedom of movement.Sows were housed in one of two farrowing accommodation treatments: conventional farrowing

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Small molecule drug discovery targeting the JAK-STAT pathway

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway functions as a central hub for transmitting signals from more than 50 cytokines, playing a pivotal role in maintaining hematopoiesis, immune balance, and tissue homeostasis.Dysregulation of this pathway has been implicated in various diseases, including immunodefic

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